Typographie can be a tricky thing – for example:
Mary had a little lamb, its fleece1 was white as snow,
and everywhere that Mary went, the lamb2 was sure to go.
So how to avoid a line-height inconsistancy here?

sub, sup {
  font-size: 0.75em;
  line-height: 0;
  position: relative;
  vertical-align: baseline;
}